EQUINE SHIVERS
A Practical Guide For Horse Owners
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Bartonellosis in Horses: Part One

The Bartonella Horse





Copyright June 1, 2013 by Brenda Bishop, VMD
All rights reserved.
No part of this publication may be reproduced, stored in a retrieval system or transmitted, in any form or by
any means, without prior written permission of the author.





Bartonellosis (bacterial infection with any one or multiple Bartonella species) in horses has escaped the
notice of horse owners and equine veterinarians for so long that it now exists in epidemic proportions.  Any
environments where horses congregate, horse shows, race tracks, sale barns, boarding facilities, etc. are
certain to have Bartonella horses in their midst.  The fact that this tiny intracellular bacterium has eluded our
detection for so long is a testament to its sophisticated biology.  Humans are so ignorant about Bartonellosis
in horses that what little we know about it amounts to ‘the tip of the iceberg’ in comparison to what we don’t
know.  As custodians of our equine partners, we CAN train ourselves how to recognize Bartonella in a horse
early in the course of the disease.  Failure to do so results (years later) in an assortment of dysfunctional
systems which can promote the development of autoimmune problems such as Shivers, Equine Recurrent
Uveitis and Autoimmune Hemolytic Anemia.

Bartonellosis is a disease within bundles and the biomechanical consequences thereof.  All the different
Bartonella species are opportunistic pathogens; they are acquired through the bite of a blood sucking
arthropod, i.e., ticks, mosquitos, fleas, horse flies, etc.  Once in the bloodstream they congregate in
endothelial cells which line blood vessels.  Periodically (it is postulated once every five days) they shed into
erythrocytes; by penetrating red blood cells they effectively hitch a ride to any part of the body supplied by
blood.  Their victims become symptomatic when a critical mass is reached within specific bundles of
vessels.  Like other mammals, horses have arteries, veins, lymphatics and nerves that run together in
bundles like tree trunks that branch to every part of the body.  Major bundles in the front limbs are located
under the shoulder area (brachial plexus); major bundles in the hind limbs are in the groin area under the
femur (inguinal plexus).  As these bundles are progressively compromised, the respective limbs served by
them display biomechanical effects of profound restrictions on arterial perfusion, venous drainage, lymphatic
drainage and nerve supply.  The protraction phase of the forward stride is delayed and a virtual partial
paralysis appears.  If the limitation is marginal, a ‘shoulder lameness’ or ‘stifle lameness’ may not yet be
evident.  However the horse will keep pulling front shoes off with the hind feet, usually from the diagonal
opposite front foot of the hind leg in the most pain. Careful examination of the groin area will reveal ‘cording’
of the lymphatics and muscles above and behind the stifle. (pictures *)

Enlarged lymph nodes, arthropathy (lameness), lethargy and bleeding due to thrombocytopenia (low platelet
counts) are symptoms common to dogs, cats, humans and horses.  Of the many species of mammals
vulnerable to Bartonella infection humans have been studied the most; the best known types are referred to
as ‘cat scratch disease’ and ‘trench fever’ (Baronella henselae and Bartonella quintana respectively).  
Infected humans can have dozens of health problems involving the heart, skin, the central nervous system,
the eyes, skeletal muscles, the lungs, the gut and the lymphatic system.  Cats with Bartonella typically display
inflammatory reactions at these same soft tissue sites.  Horses display subtle symptoms early in the course
of infection, for example, muscle cramps, sore ribs, chronic fatigue, fibromyalgia, ‘stiff legs’, urinary
discomfort (standing parked out), respiratory problems, hypersensitivity to anything that touches the skin,
sore soles, patchy sweating, ulcers, heart valve insufficiencies (heart murmurs), and eye problems
(conjunctivitis, uveitis, dry eyes and/or distorted vision).  Horses with different species of Bartonella can
eventually exhibit any or all of the above plus an assortment of dramatic unruly behavior patterns emanating
from the brainstem (encephalopathy): dizziness, head shaking, strokes, confusion, explosive outbursts,
aggression, rage, agitation, attention deficit, seizures or depression. (video **)


Good detective work requires a thorough collection of background information (history taking) from which
patterns emerge.  In the case of Bartonellosis, an overall pattern of dysfunction is more significant than any
one of the countless variables.  No two horses with this disease will look the same because no two horses
will have the same combination of Bartonella species and/or the same absolute numbers of bacteria in the
same soft tissue bundles.  Different patterns will most likely be correlated with specific species of Bartonella
sometime in the future (“Bartonellosis in Horses: Part Two”), when current laboratory testing methods
become more refined.  Given the widespread presence of infection in horses, cattle, dogs, cats, deer, elk,
coyotes and other wild animals, the slightest suggestion of a pattern consistent with Bartonella allows us to
make a good argument for treatment.  As is the case with cats, horses can be successfully treated with a
conservative dose of antibiotics once daily for 5 or more days.  Most horses go through a healing crisis on the
second or third day and return to total soundness of mind and body within two weeks.  An ultra conservative
dose of Azithromycin paired with Rifampin (2 mg per pound per day of each antibiotic) is readily absorbed by
the oral route and can be administered as a compounded paste.  Doxycycline (10 mg per pound twice daily)
paired with Rifampin (2 mg per pound per day for 5 days) can also be used orally.  Doxycycline is particularly
useful if a simultaneous infection with Lyme disease and/or Leptospirosis is present, in which case it can be
administered for a much longer period (up to eight weeks).  Exposure to heat and sunlight must be avoided
when using Azithromycin (due to risk of hyperthermia) and limited when using Doxycycline.   

Our willingness to even suspect the prescence of Bartonella in a horse with multiple unresolved medical
issues is the key that opens ‘Pandora’s box’ with respect to a wide range of problems.  Head shaking,
recurrent exertional rhabdomyolysis (tying-up), chronic equine protozoal myelitis, chronic stomach ulcers,
exercise induced pulmonary hemorrhage (bleeding from the nose on exercise), chronic obstructive
pulmonary disease, lymphangitis, purpura, narcolepsy and seizures are just some examples of accepted
diagnostic labels for which band-aid treatments are more often than not unsuccessful in the long term.  By
recording a horse’s rectal temperature at the same time every day, a chart can be created which will
demonstrate a low grade cyclic fever pattern that will coincide with sudden lethargy, poor appetite and active
shedding of the organism into the circulation.  Shivers horses with Bartonella require special handling, i.e. a
titrated dosing regimen.  They typically develop soft manure or diarrhea and should be monitored for
abdominal discomfort; antibiotic therapy amounts to a stress on an already compromised immune system.  
Age and length of infection factor into the decision to attempt treatment.  Older horses with Shivers are
extremely fragile patients immunologically especially if they harbor multiple species of Bartonella.  
Autoimmune problems tend to cluster and antibiotics which effect a massive kill of bacteria within
erythrocytes can precipitate autoimmune hemolytic anemia.  Pulse dosing might prove useful as treatment
protocols are developed and standardized based upon future improvements in laboratory testing.  For any
horse living with Bartonella a balanced diet rich in vitamins B1, B2, B3, B5, B6, B9, B12, C and E can only
enhance the chances of a complete recovery from this elusive bacterial pathogen.  



Pictures *     3 geldings with inguinal lymphangitis and cording of skeletal muscle and 1 gelding with  
brachial cording of the lymphatic branches.

Video **   11 year old thoroughbred gelding before and after treatment for Bartonellosis






The author wishes to thank Jack Broadhurst, DVM (The Cat Health Clinic), Lisa Crescenzi, Lisa Oldroyd and
Neil Schwartzberg for their personal contributions over many decades to animal welfare and to the
advancement of veterinary knowledge for the benefit of all.




Bartonellosis in Horses: Part Two


Treatment Considerations




Copyright January 1, 2014 by Brenda Bishop, VMD

All rights reserved.

No part of this publication may be reproduced, stored in a retrieval system or transmitted, in any form or by
any means, without prior written permission of the author.




Nearly all autoimmune diseases in humans can be traced back to a specific primary infection, commonly
bacterial or viral.  Similarly, autoimmune scenarios in horses result from a cascade of events that involve
immune system damage and specific infectious agents. Which of these two components came first is of little
consequence in the long run because each can facilitate the other, usually synchronistically.  Biting insects
can transmit a plethora of infectious organisms with just one bite.  Horses living in natural settings are prime
candidates for insect bites especially when heavy rains flush ticks out of wooded areas into open pasture
land.  While Lyme disease is the classic infection associated with ticks, the reality is that the same tick can
and often does inject more than one bacterial pathogen into the host horse’s bloodstream.  Chief among
these is one or more species of Bartonella.  Infections become chronic because both Lyme and Bartonella
bacteria can disable (suppress) immune systems.  Once a Bartonella infection becomes well established,
the trajectory is toward an autoimmune state; for example, not all Bartonella horses ultimately become
myasthenic horses but all Shivers horses are Bartonella horses (i.e., infected with one or more species of
Bartonella) until proven otherwise.  This is a perfectly safe assumption to make due to the current lack of a
definitive laboratory test for Bartonella in horses.  (There is no definitive test for Fibromyalgia or Chronic
Fatigue Syndrome either.)



Probably the most important internal characteristic of a Bartonella infection is virtual annihilation of the horse’
s magnesium levels.  Magnesium is needed by both Lyme and Bartonella species to multiply and the longer
an infection persists, the more depleted the horse’s body becomes.  The most obvious external hallmark of a
Bartonella infection is a shortened forward stride length, especially when moving downhill.  A helpful
diagnostic exercise is to supplement the adult horse with oral magnesium (20 to 40 grams a day for a one
thousand pound horse) for one to two weeks.  If the stride length improves dramatically (especially going
down a slope), a Bartonella infection can be considered likely.  Invariably a fungal co-infection will be lurking
in the background as well (see “The Fibromyalgia Syndrome (FMS) Horse”).  In the case of foals and young
horses, magnesium depletion will not have escalated yet but contracted tendons or any tendency toward
overly straight legs is grounds enough for suspecting the presence of Bartonella.  Kittens infected with
Bartonella henselae commonly exhibit extensor tendon rigidity until they are treated with appropriate
antibiotics.  Restoration of magnesium levels (by the IV route, transdermally and/or orally) can be started two
weeks before antibiotic therapy and will facilitate immune system recovery.  In addition, access to a free
choice mineral block (‘magnesium block’) should be provided at all times to help the horse’s body rectify
long standing deficits.



Leaky gut syndrome, a common denominator in autoimmune disease, also contributes to loss of
magnesium and other minerals from the gut.  The horse is a grazing animal; when enough stress triggers
the development of bleeding ulcers in the stomach and diffuse ulceration in the hindgut, the lining of the
gastrointestinal tract becomes a greenhouse for pathogenic bacteria and fungal overgrowth (usually
Candida).  Chronic inflammation distorts the integrity of the intestinal wall; an overly porous gut lining
resembles a formerly one way street that has turned into a two way street.  Microbes and toxins that would
normally be contained enter the bloodstream; minerals and other micronutrients that would normally be
absorbed pass on through the other end of the horse.  Leaky guts have poor efficiency ratings across the
board.  Ulcer remedies make good band-aids but will not reverse the problem.  In some horses transit times
start changing, either too fast (diarrhea) or too slow (constipation).  Depending on other environmental
stressors such as the weather, colic can result.  Putting the horse on a hypoallergenic (high fat low
carbohydrate moderate protein) diet is the best way to start reversing the problem.  Carbohydrate loading with
high gluten content grains (wheat, barley, oats) should be minimized and replaced with a good fat source
such as rice bran meal.  Beneficial supplements for leaky guts include aloe vera juice, apple cider vinegar, n-
acetyl-glucosamine, and all the B vitamins along with C and E.  Grape seed extract is particularly suitable for
a Bartonella horse; it contains resveratrol which lowers a potent neurotoxin linked to depression (quinolinic
acid) and helps detoxify the body in general.  Along with magnesium supplementation, immune support is
vitally important before, during and for at least two months after specific drug therapy.  Our use of big guns
(antibiotics) wrecks havoc on the battlefield (the horse’s body) and the foot soldiers (immune system
components) need to be re-supplied consistently.  



Bartonellosis can be caused by any one or any combination of numerous Bartonella species.  The
appropriate ‘antibiotic of choice’ can be determined by taking into consideration the affected horse’s
symptoms, age, breed, history and overall condition.  A five day course of Azithromycin is very effective for
reducing enlarged lymph nodes.  It is not a good choice for older immunodeficient horses or any horse with
long standing   leaky gut syndrome.  Doxycycline is a good choice for a Bartonella horse with neuroretinitis,
particularly if the horse has been diagnosed with Equine Recurrent Uveitis (ERU), as well as a horse that is a
suspected Lyme disease case.  Both Azithromycin and Doxycycline should be paired with Rifampin (see Part
One “The Bartonella Horse” for dosages).   Rifampin is a particularly good choice for horses with any of the
psychiatric and/or neurological manifestations of Bartonellosis: panic attacks, mood swings, extreme anxiety,
seizures, narcolepsy, extreme depression, etc.  Rifampin has several disadvantages: it is highly unpalatable,
it requires that blood counts and liver function be monitored regularly while using it, it can cause headaches,
and Rifampin increases cytochromes, enzymes that speed metabolism of other medications.  If the horse is
on pain medications, he (she) will require higher doses of those drugs during the treatment period.  
Complicated cases of Bartonellosis are best treated with two antibiotics simultaneously.



Horses that are fragile immunologically can be successfully treated with three drugs that are familiar to most
horse owners: Fenbendazole, Ketoconazole and Sulfamethoxazole.  All share a common biochemical
structure (azoles), all enjoy a high margin of safety, all are fairly palatable, and all are easy to administer.  
Fenbendazole given at the labeled larvacidal dose (a double dose a day for five days) addresses leaky gut
syndrome, reduces Candida overgrowth in the large intestine, dries up ulcers, has a synergistic effect on
leucocytes (white blood cells that fight infection), and jump starts the immune system.  Many horses show
improvement in their Bartonella symptoms by the fifth day.  Ketoconazole can be started on day six and
continued for up to four weeks.  The same conservative dose used for Fibromyalgia (2 mg per pound per day)
can be added to the feed once daily for three to four weeks (see “The Fibromyalgia Syndrome (FMS) Horse”).  
The azole derivatives (unlike other fungicidal drugs) are remarkably useful due to their broad spectrum of
activity: they are active against fungi, yeasts, some protozoa and some bacteria, specifically Bartonella.  
Sulfamethoxazole is a large white tablet (“Trimethoprim/Sulfamethoxazole” or SMZ) that readily dissolves in
water and can be added to the feed twice daily at the labeled dose for up to eight weeks.  It has some activity
against Lyme bacteria as well but requires longer duration of treatment for maximum results against
Bartonella compared to other antibiotics.  The azoles are good choices for horses under 4 years of age (with
immature immune systems), horses over 18 years of age (with tired worn-out immune systems) and horses
of any age in poor overall condition (unthrifty appearance, high parasite load, dull haircoat, etc.).  ‘Routine’
vaccination should be avoided at all costs; it creates unwanted additional chaos for handicapped battered
immune systems, adding fuel to the fire of chronic Bartonellosis.    







Resources





www.horsetech.com                             1-800-831-3309                                      
rod@horsetech.com      “Custom Product # MS-010514”   (daily vitamin mineral supplement)



www.PerformanceEquineUSA.com      1-707-766-8624            

performanceequine@pacbell.net.          “Mag Restore”   (daily magnesium supplement)



www.EquiVision.com                            1-859-873-1220

dr.bill@equivision.com              “EC”    (daily vitamin E vitamin C supplement)                     






Bartonellosis in Horses: Part Three

Alternative Approaches





Copyright September 1, 2014 by Brenda Bishop, VMD

All rights reserved.

No part of this publication may be reproduced, stored in a retrieval system or transmitted, in any form or by
any means, without prior written permission of the author.




Horse owners in the twenty first century have easy access to a wide range of treatment modalities, the vast
majority of which (with respect to a Bartonella horse) amount to sophisticated temporary quick fixes.  Immune
dysfunction in the host horse, the result of a disabled immune system, is an important aspect of both Lyme
disease and Bartonellosis.  The implications of this ground zero damage are weighted heavily in favor of the
acquired bacteria, amounting to a David and Goliath situation.  The microscopic invader simply catches a
ride to anywhere the horse’s red blood cells travel, including the brain, reducing the availability of nutrients
and oxygen everywhere it goes; simultaneously it feeds on the host’s supply of available magnesium,
engendering chaos within the horse’s body chemistry: energy availability, necessary enzymatic reactions,
electrolyte flow, elimination of metabolic waste products, etc.  This is why a Bartonella horse never has
normal manure.  Horses are grazing animals; their manure is a mirror for their internal state of health.  
Simple routine observation of their manure (quantity, consistency, color, etc.) is a highly accurate means of
gauging whether any attempted treatment has actually eliminated the infection.  A passing glance on a
regular basis is all that is required.  

Bartonella is considered a ‘stealth pathogen’.  This is because it is a shifty clever bacterium.  It leaves the
various locations where it has set up housekeeping (endothelial sites lining the blood and lymphatic
vessels) to travel through the bloodstream at regular intervals, usually every so many days.  For infected
horses, some days are better than others; they are consistently inconsistent in their ability to focus and do
their jobs.  When veterinarians initiate antibiotic therapies, Bartonella bacteria have the ability to go into
hiding, back to their various niches throughout the body.  In this respect the bug is adept at going to work only
on odd days when left unmolested and when challenged, going on long vacations.  Big guns such as high
tech antibiotics will take a toll on the horse’s bacterial populations to be sure.  Unfortunately for the horse,
there are a number of down sides to this approach: a certain number of healthy useful bacteria are killed in
the process even with concurrent use of probiotics; many antibiotics do not cross the blood brain barrier; and
even after prolonged administration (60 days or more of Doxycycline for example) the bacteria can come back
out of hiding only to start multiplying and traveling again as if with a vengeance.  Typically around 6 to 12
months down the road, it becomes abundantly clear that the infection has secured a firm foothold in the
central nervous system; the horse endures odd panic attacks that appear unjustified, might become
argumentative and even aggressive, and/or has unmistakable periods of attention deficit.   

It would seem that Bartonella horses are doomed to be lifelong carriers of this infection.  Certainly we cannot
help them become 100% infection free using only conventional, that is to say Western, reasoning.  Alternative
medicine on the other hand offers us a viable avenue that is horse friendly, user friendly, and unencumbered
with any down sides.  As we examine more fully the mechanism of action of the various Bartonella bacteria, it
becomes clear that those neurochemicals classed as neurotransmitters rule the day. (This group includes
Acetylcholine, Serotonin, Dopamine, Epinephron, Histamine and many others.)  A compelling demonstration
that this is the case is the example of Shivers horses; their immune systems have been stressed to the
extreme, to the point of no return, i.e., the autoimmune state. When their Bartonella infections are eliminated
these horses steadily improve toward the status of being nearly Shivers free.  (Attention to correction of
magnesium depletion enhances their degree of improvement and allows for ongoing recovery.)  Their
peripheral neuromuscular junctions will still reflect the presence of autoantibodies, either calcium channel
antibodies or acetylcholine receptor antibodies (or rarely both) but they will enjoy a much higher overall quality
of life.  Freedom from infection can be achieved through the use of various herbal formulas added to the feed
over a 45 to 90 day period.  Magnesium can be supplemented until a desired comfort level is achieved.  (See
“Resources”)  Successful handling of Shivers cases mandates that treatment protocols promote both
healing of damaged neurons and neurotransmitter balancing where the problem begins, upstream at the
level of the brain. Another example of the fundamental role of neurotransmitters is the drastic improvement
noted in cribbers when treated for their Bartonella infections, usually to the point wherein a cribbing collar is
unnecessary.  Generally considered an unwanted behavior which escalates in times of stress, cribbing
allows the horse to self medicate himself by stimulating the pituitary gland at the base of the brain to release
endorphins.  Higher endorphin levels help offset low dopamine levels, a characteristic of chronic
Bartonellosis.  As with all Shivers horses, by virtue of the fact that no other treatment alleviates the problem to
such an overwhelming degree, all cribbers should be considered Bartonella horses until proven otherwise.  

Explosive outbursts, bucking, aggression toward humans and/or other horses, panic attacks and violent
pulling back while tied are some of the behavior patterns typical of low levels of magnesium and/or
Dopamine.  Bartonella horses have miniscule levels of both so their behavior can be quite dangerous.  Being
hypersensitive to touch they dislike being groomed.  Standing on the ground near them or riding them, it
should be abundantly clear that ‘a Bartonella horse can kill you’.  Other signs of magnesium depletion
include: separation anxiety, sudden shying for no apparent reason, nervous habits, short attention spans,
insulin resistance, a grass belly even on little grass, tying-up, excessive sweating in summer, shivering in
cold wet weather, sweet itch, watery eyes, sore feet, laminitis and shortened stride length especially going
down hill.  (This is due to inappropriate toe-first landing of the hoof which is difficult for the horse to achieve
on a downward slope.)  It takes a long time (up to one year) to correct magnesium depletion in a horse
whose body has been continuously drained round the clock by Bartonella bacteria.  Hair analysis is an
accurate way to identify abnormal levels of various minerals and metals in the body.   Horses store toxins in
their body fat and their hair.   Discovery of heavy metal toxicity can be likened to a pre-purchase exam; it
pinpoints specific needs for detoxification before precious time and money are wasted.  If a horse is toxic due
to high levels of selenium or lead for example, chelation therapy will be required to eliminate specific toxins
prior to treatment for chronic infection.  High levels of lead will reduce magnesium, calcium and iron
absorption, contributing to the problems of low magnesium and reduced oxygen carrying capacity of red
blood cells.  



Neurochemical imbalances created by Bartonellosis ensure that the affected horse will eventually go ‘out of
his mind’.  Research on Parkinson’s disease in humans has established that part of the midbrain, the
Substantia Nigra (SN), accounts for the neurochemical basis of the disease.  The dopaminergic neurons of
the SN play an indirect role in motor control; they account for dexterity of the legs for example.  These neurons
can generate insufficient Dopamine (as in Parkinson’s disease) or an excess of Dopamine (as in humans
with Schizophrenia).  Different neurotransmitters balance each other; if one is high or low, the others will be
impacted.  Bartonella horses have low Dopamine levels as well as low Acetylcholine levels as a result of
cellular damage to these important neurons.  Before total eradication of infection can be achieved, the
individual cells must be cleared of the bacteria first.  Herbs can do this job in as little as 15 days.  
Subsequent regeneration of healthy neurons in the SN (as well as other parts of the nervous system) can be
jump started by feeding appropriate herbal formulas over a minimum of 30 days.  In the case of a Shivers
horse, simultaneous addition of specific formulas that raise individual neurotransmitter levels (for example
Acetylcholine or Dopamine) helps maximize the overall healing process.  Working with the body instead of
against it, these herbal formulas are adaptogenic.  They exert a normalizing influence on the body,
irrespective of the direction of the imbalance.  Adaptogenic herbs normalize neurotransmitter production;
neurotransmitters continue to assume their functions, one of which is to rebalance each other.  
Comprehensive healing happens naturally.  Steadily the horse emerges into a calmer happier state of being,
the behavioral polar opposite of a Bartonella horse.  Best of all, herbs have the ability to do the job right the
first time; re-treatment is a non-issue.  At the end of the day conventional manufactured antibiotic regimens
are not even on the same playing field.  Prolonged daily magnesium therapy is indispensable for supporting
total recovery.  For horses with Bartonellosis the holistic approach serves the whole horse quite nicely.





“Any intelligent fool can make things bigger, more complex and more violent.  It takes a touch of genius – and
a lot of courage – to move in the opposite direction…… The most beautiful thing we can experience is the
mysterious.  It is the source of all true art and all science.  He to whom this emotion is a stranger, who can no
longer pause to wonder and stand rapt in awe, is as good as dead: his eyes are closed.”      - Albert Einstein



Resources


www.EffectivePetWellness.com                        719-357-9692                           

“Lyme Kit”,  3 different “Shivers Kits” (various combinations of “Horse Clear”, “Clearacell”,  “Neuro ReGen”,
“Dopamine Max”, “SN ReGen”, “Reticulo”, “Acetylcholine Max”, “Erythro Pro”)

www.PerformanceEquineUSA.com                        707-766-8624    

“MagRestore”, “Focus Equine” (and article “Magnesium: The Mineral Superhero”)

www.depaoloequineconcepts.com                        940-686-9111

Horse Hair Analysis (and numerous articles by Mark DePaolo, DVM)

www.galaxydx.com                                        contact@galaxydx.com
“Enrichment PCR testing and DNA sequence verification” (the gold standard in Bartonella testing)




Bartonellosis in Horses: Part Four

Applied Concepts




Symptom Based Analysis and Strategic Treatment Design



Copyright May 1, 2016 by Brenda Bishop, VMD.

All rights reserved.

No portion of this publication may be reproduced, stored in a retrieval system or transmitted, in any form or by
any means, without prior written permission of the author.


“My aim is to help the reader share in my understanding.  But a text can only act as a scaffolding of concepts,
a ladder for others to climb.  Real knowledge of what I am saying must be earned, and lived, by each
individual, in his or her own way.”                      -Daniel Pinchbeck                                                                           

“You cannot connect the dots looking forward; you can only connect them looking backwards.”  -Steve Jobs


Horses with chronic Bartonellosis can present owners and veterinarians with a complex array of seemingly
unrelated symptoms, problems, surprises and occasionally dangers.  Murphy’s Law (anything that can go
wrong will go wrong, at the worst possible moment, in the worst possible context) rules for these horses
regularly.  Their human partners, armed with enough clarity about Bartonella’s mechanism of action, have
ample opportunity to set these horses right.  Infection fighting formulas such as the “Bartonella Kit” (www.
effectivepetwellness.com) paired with magnesium supplementation (www.performanceequinenutrition.com)
are always and in every case the first steps toward resolution.  These steps could be called Stage One. The
order in which treatments are administered is important because a lingering infection will eventually derail
any and all other interventions whether simple or sophisticated.  Key to effective treatment planning is a
healthy respect for Bartonella’s game plan.  Upon entering the bloodstream the first thing this bacterium
does is annihilate the horse’s immune system.  One cannot afford to underestimate the efficiency with which
it accomplishes this.  The inevitable cascade(s) of subsequent issues (multitudes of problems months and
years down the road) that share a common computer malfunction (a compromised immune system unable
to handle stress) will progress and converge along specific logical pathways.  Strategies designed to
facilitate normalization of multiple system interconnectedness will reduce overall demands on the
handicapped immune system.  Any such advanced approaches to treatment will be exponentially more
successful when applied after infection is initially addressed.

Targeted treatment plans are an art form in that a total body focus and penetrating insight are necessary to
achieve the desired result, as exemplified by traditional Chinese medicine (TCM).  Due to the multiple
variables within each case history, the almost infinite possible combinations of overt symptoms (see
“Symptom Check List”), and diversity within management situations, there is no ‘one size fits all’ Stage Two.  
The relatively small percentage of horses (about 20% in the author’s experience) that require additional
treatment after completing Stage One will need custom tailored protocols.  Layers of problems stemming
from deeper pathology built up over time can be debrided (removed) like taking skin off an onion.  The
primary over-riding principle to comprehend is the fact that ***Bartonellosis is a disease of microcirculation
failure***.  The bacterium colonizes inside red blood cells (erythrocytes), on endothelial cells (the innermost
linings of arteries, veins and capillaries) on collagen (i.e., connective tissues such as tendons, ligaments
and their sheaths), and potentially anywhere circulating blood goes.  Being a stealth pathogen, it has a
predilection for good hiding places such as the bone marrow, the spleen, liver, kidneys, pericardium and
brain.  Unfortunately for the infected horse, these remote sites are rarely examined, perhaps at autopsy.  
Eventually the infection will establish residency in the mid-brain leading to neurotransmitter imbalances and
an array of downstream conundrums.  An easy way to remember the more obvious locations where
symptoms can be appreciated is to consider the parts of the horse’s body farthest from the heart: the skin
(integument), the feet, the back, the ribcage, the pelvic girdle and hind limbs, and the head from the bottom of
the nose back to the upper cervical area.  

The numerous ramifications of Bartonella induced circulation failure can be difficult to recognize because
individual horses experience downstream effects of circulation deficits in a number of possible ways.  A
spectrum of vital functions are increasingly delayed; examples are prolonged circulation time, reduced
hemodynamic flow (blood stasis), prolonged healing, prolonged clotting, and prolonged muscle contraction
with or without delayed forward phase of stride. The subtle biomechanical result that surfaces as ‘chronic
fatigue’ is sometimes overshadowed by more dramatic symptoms that develop spontaneously.  The body
finds ways to compensate (coping mechanisms) that may or may not include intermittent lameness, different
ways of going, shifting leg lameness, bridle lameness, added strain on supporting limbs, etc.  Some horses
exhibit a pattern of tendon / ligament / foot soreness that includes blood pooling in the feet.  Dormant
abscesses can form at the back of the foot and remain quiescent for months, only to ‘wake-up’ suddenly
when the horse is suddenly stressed.  Such lameness that appears to have an acute onset has actually
been silently simmering, ready to flare when fatigue becomes intolerable.  If these abscesses have been
sitting in the feet long enough they can calcify and show up on radiographs.  An appropriate Stage Two for
this scenario (digital suspensory syndrome) is the “Nitric Oxide Pathway Formula”: Jiaogulan, basilicum and
AAKG (arginine alpha ketoglutarate) (www.copperfieldequinetherapy.com).  The objective is reperfusion of
tissues starved for oxygen which consequently fosters clearance of metabolic waste products, toxins and
cellular debris.

Intrinsic communication between the immune, endocrine and central nervous systems, when seriously
impaired, can generate a pattern of blatant episodes characterized by tissue destruction accompanied by
profuse bleeding, typically triggered by a stressful (high serum cortisol inducing) event such as a horse
show, a race, vaccination, a long haul, excessive work, an adverse drug reaction, and/or a secondary
bacterial or viral infection.  As with digital suspensory syndrome, the parts of the body farthest from the heart
suffer the most damage.  Examples are ruptured alveoli deep in the lungs (exercise induced pulmonary
hemorrhage (EIPH) (aka Bursting)), torn large muscles of the hindquarters (recurrent exertional
rhabdomyolysis or tying-up (RER)), hindgut (colonic) bleeding ulcers, endocrinopathic laminitis (tearing away
of the soft laminae from the outer hard lamellar wall), exercise induced trigeminal neuralgia (pressure on the
trigeminal nerve(s) running from the brain to the lower face), purpura haemorrhagica (vasculitis and leakage
of blood into soft tissues with pooling in the lower legs, head and underbelly) and autoimmune hemolytic
anemia.  Individuals with resting high blood pressure (normally balanced by the endocrine system) are at
higher risk for these events.  In the case of laminitis, a ‘bounding pulse’ can usually be palpated over the
posterior digital arteries and the external hoof can be hot.  Slightly less catastrophic examples of endocrine
dysfunction are subclinical laminitis (especially in easy keepers), equine metabolic syndrome (EMS),
Cushing’s syndrome (high serum cortisol due to elevated ACTH courtesy of low dopamine), anhidrosis (non-
sweating) and cystic ovaries in mares.  A reasonable Stage Two for this group of horses is appropriate
magnesium supplementation coupled with transdermal skin patches that re-balance the horse’s electrolytes
(minerals that carry an electric charge such as calcium, potassium, magnesium, etc.) (www.signal-health.
com).  Bleeding ulcers can be addressed concurrently with the supplement Succeed, which restores
healthier acid-base balance and simultaneously promotes healing necessary for reversing leaky gut
syndrome (www.succeed-equine.com) thereby re-establishing necessary absorption of nutrients like
vitamins and minerals.   

Bartonella horses that have endured chronic infection for years are inevitably destined for autoimmune
states.  These cases have acquired central nervous system (cranial nerves, brain and spinal cord)
involvement that can prove frustrating for the horses as well as their owners.  Strategic planning for this group
is like closing the barn doors after the horse has escaped.  The ratio or gap between cortisol and dopamine
(neurochemicals that are inversely proportional) has widened.  By the time acetylcholine receptor antibodies
and/or voltage gated calcium channel antibodies start appearing, Shivers horses already have damage in the
substantia nigra of the mid-brain, not unlike humans with Parkinson’s disease (see “Clinical Aspects of
Myasthenia (‘Shivers’) in Horses”).  Mid-brain dopaminergic neuron destruction for example can be
addressed with herbal formulas that target specific neurotransmitters such as dopamine and acetylcholine
(www.effectivepetwellness.com).  Also at the head end of the body, cranial nerves such as the optic nerve(s)
can be irritated to the point of eventual Moon Blindness (also known as equine recurrent uveitis or ERU).  It is
no coincidence that both descriptive names for this condition reflect characteristics of a chronic Bartonella
infection; most cases have flare-ups around a full moon and nearly all cases are cyclic, i.e., recurrent.  Both
intense and quiescent intervals of painful hypersensitivity to strong light and watery weepy eyes can be
managed with herbal formulas (“ERU acute” and “ERU maintenance”) designed to deliver maximum relief
according to real time symptom evaluation (www.wholehorse.com).    

Autoimmune conditions tend to cluster, so the odd horse can have any combination of calcium channel
antibodies, acetylcholine receptor antibodies and/or potassium channel antibodies.  Voltage gated
potassium channel antibodies with peripheral (farthest from the heart) myoclonus (muscle spasms)
(“Morvan’s syndrome”) can manifest as periodic autonomic dysfunction: feverish thermoregulation (higher
than normal body temperature), hyperhidrosis (excessive sweating), erythema  (congested capillaries,
obstructed sweat glands and spontaneous patchy sweating), intense pruritis (itching, mainly the head and
groin areas), seasonal asthma, excessive salivation, laryngospasm (spontaneous hyperventilation at rest),
weight loss, constipation, herring-gutted appearance, and/or muscle cramping (fasiculations) in the front
legs and/or quadriceps.  A simple intervention that serves these cases beautifully is freeze dried chopped
garlic, one teaspoon in the feed twice daily.  Garlic is a potent antihistamine; in addition it has mild anti-
cholinergic properties.  Autonomic functions such as salivation, thermoregulation (which includes sweating)
and asthmatic breathing are dialed up when the operative neurotransmitter, acetylcholine, is out of balance
(excessive).  These symptoms are exacerbated by dangerously low dopamine.  Garlic achieves its result by
closing the wide gap (improving the ratio) between too much acetylcholine and insufficient dopamine, while
simultaneously counteracting too much of another neurotransmitter, histamine.  Ideally one would pair garlic
(neurotransmitter balancing) with transdermal skin patches (electrolyte balancing); electrolyte balance is
crucial for proper neurotransmitter functioning.  These horses also benefit from liver detoxification (www.
OmegaAlphaEquine.com) and Succeed for ulcers.  Similarly, neuroses associated with chronic Bartonellosis
revolve around neurotransmitter imbalances and as such, can appear sporadically or continuously.  
Magnesium is indispensable especially when repetitive, obsessive compulsive, and/or attention deficit
hyperactivity type behavior surfaces.  Chronic neuroses reflecting deeper patterns of dysfunction can surface
as panic attacks, explosive outbursts, grumpiness, aggression, depression, withdrawal, OCD, ADHD, head
shaking, mouthiness, etc. in random combinations.  Custom treatment plans designed from a thoroughly
panoramic perspective can reverse negative pathways for these horses suffering from a wide array of
multiple downstream problems, convoluted web-like reflections of chronic Bartonellosis.

“Design is not just what it looks like and feels like.  Design is how it works.”  -Steve Jobs  



Resources

www.horseflynet.com / info@horseflynet.com / 434-973-0121     (barriers against flies)

www.wholehorse.com / whole horse herbs / 559-683-4434     (ERU formulas and more)

www.signal-health.com / info@signal-health.com / 877-378-4946 (transdermal patches)                    

www.holisticvetclinic.net. / Gerald Wessner, VMD / 352-245-2025 /
                                               (nosodes for Bartonella, WNV and other co-infections)
                                                                                               
www.effectivepetwellness.com / scott@effectivepetwellness.com / 866-452-2268  
                                                                                              (Bartonella Kit and more)                     

www.copperfieldequinetherapy.com / catherinecooper@eircom.net / +353 (0)62 53940
                                                                                         (custom herbal supplements)

www.succeed-equine.com / U.S. / U.K. / Australia / New Zealand                   
(Succeed)                                                      

www.PerformanceEquineNutrition.com / service@performanceequinenutrition.com /
                                                  707-766-8624                        (MagRestore and more)

www.springtimeinc.com / 800-521-3212                    (Spirulina Wafers, Bug Off Garlic)

www.OmegaAlphaEquine.com /                                                          (Chill, Liver Flush)


Bartonellosis in Horses: Part Five  

         
The Thyroid Adrenal Connection


Copyright December 15, 2016  by Brenda Bishop, VMD

All rights reserved.
No portion of this publication may be reproduced, stored in a retrieval system or transmitted, in any form or by
any means, without prior written permission of the author.


“Simple can be harder than complex.  You have to work hard to get your thinking clean to make it simple.  But
it's worth it in the end because once you get there, you can move mountains.”   -Steve Jobs


No discussion about bartonellosis in horses would be complete without reference to the adrenal glands and
the thyroid gland.  Traditional genetic classification of different horse breeds is based on basal metabolic
rate (BMR) for all cells in the body which is influenced by thyroid hormones T3 and T4.  Thoroughbreds and
Arabs have a higher BMR, most draft breeds a lower BMR and a wide range of others (American Quarter
horses, Eastern European warmbloods, pony breeds, etc.) fall somewhere in the middle.  Superimposed
upon this genetic aspect of thermoregulation, any horse with an underactive thyroid (aka hypothyroid) will
have a lower then normal core temperature (always cold and sensitive to cold weather); horses with an
overactive thyroid (aka hyperthyroid) will have a higher than normal core temperature (a tendency to run hot
and prone to heat stress).  Horse breeders have spent centuries developing breeds with desirable
characteristics based on intended use of the offspring.  Thoroughbred racehorses have a faster
neuromuscular junction (reaction) time, a preponderance of fast twitch muscle fibers, a long ground covering
stride and shorter total circulation time.  Arabians have all of these traits as well as cardiac muscle famous
for rapid recovery (endurance).  Draft horses have a slower neuromuscular junction (NMJ) time, a
preponderance of slow twitch muscle fibers, a shorter stride length suitable for pulling weight and longer
total circulation time.  The Baroque breeds (Lusitanos, Andalusians, Lippizaners, Friesians) have body types
that once served knights in battle and today excel at dressage.  Historically, alignment of desirable genetic
traits with specific job descriptions is nothing new.  But specific manifestations of thyroid and adrenal gland
malfunction within different gene pools during times of chronic stress (years for some horses) are poorly
understood.  While human horse breeders have been honing their skills over generations, stealth bacteria
such as Bartonella species have been improving their own skills, becoming adept at scavenging and
systematically depleting key vitamins, minerals and amino acids essential for the body's defense systems,
components of the immune system.  Simultaneously these opportunistic invaders appear to have achieved a
ramped-up level of pathogenicity, aided in part by 21st century stressful environments within and outside the
body, contributing to a complex matrix of chronic inflammatory issues.

Bartonella can distribute itself anywhere the horse's blood goes and establish itself in a variety of tissues
which translates into long term survival for the bacteria and a convoluted trip to Hades for the horse.  As a
stealth pathogen in a league of its own, it maneuvers from every conceivable angle of attack.  Bone marrow,
vessel linings and collagenous tissues such as tendons and tendon sheaths, the liver and spleen, all
places where replication can proceed in relative obscurity, are subject to invasion. Infected horses suffer a
spectrum of possible 'symptoms' in relation to the specific multiple loci (locations) of bacterial presence and
eventual cellular damage.  Neuroscientists know that any significant ongoing stressor attacks cells of the
hypothalamic-pituitary-adrenal axis; along with the hypothalamic-pituitary-thyroid axis, two systems that
connect the body with the brain, the entire central nervous system is vulnerable to attack.  Bartonella is a
neurotoxic pathogen; neurotoxins disproportionately affect the hypothalamus, creating dysregulation of
downstream hormones.  The thyroid and adrenals help mediate a host of natural defense mechanisms but
working under stress, they become deranged as exemplified by overactivity of the adrenal cortex aka
Cushing's.  Autoimmune problems tend to cluster and Bartonella horses can develop autoimmune thyroiditis
and/or Low T3 Syndrome, an autoimmune disease rarely considered; in the brain the hypothalamus
produces thyrotropin releasing hormone (TRH) which passes through the bloodstream to act on the anterior
pituitary gland which secretes thyrotropin aka thyroid stimulating hormone (TSH).  TSH acts on the thyroid
gland to up regulate T3 and T4 synthesis.  InactiveT4 is converted to active T3 by multiple tissues, many of
which can shelter Bartonella bacteria: the gut lining, the liver, and the brain among others.  T3 requires
transport proteins made by the liver to make its journey to the thyroid receptors located within cell
membranes of final destination tissues such as laminae in the feet, alveoli in the lungs, delicate tissues of
the eyes, and skeletal muscles closer to the pelvic girdle.  Failure within any one or more of these stages,
with or without pathology in the thyroid itself, can result in low T3.  

Chronic infection impinges on thyroid function coming and going.  Across species lines there is a two way
street between thyroid function and gut health.  The gut is ground zero for the immune system, for example,
most of a horse's serotonin is manufactured in the gut.  A compromised thyroid gland with or without Low T3
Syndrome opens the door for a degenerative gastrointestinal spiral; without thyroid hormone present in cell
membranes, neurotransmitters will not activate (excite) neurons at the neuromuscular junction; muscle
contraction is delayed; the gut lining remains flaccid and porous, unable to absorb nutrients and water, and
leaky gut syndrome (LGS) develops.  (By the same mechanism, insufficient thyroid hormone in multiple
tissues engenders delayed neural transmission.)  Horses with leaky guts have skewed neurotransmitter
production, malabsorption of necessary nutrients, and environments conducive to fungal overgrowth (usually
Candida).  Another aspect of stealth infection is chronic inflammation which fuels elevated angiogenic
cytokines (the immune system shifts between a Th1 response and a Th2 response) and over-activation of
pro-inflammatory interleukins.  This inflammatory cytokine cascade can block cellular thyroid hormone
receptors even in the presence of adequate T3 and T4.  Neurotoxins can also block these receptors; as
minerals are steadily depleted by Bartonella bacteria, heavy metals move in and occupy the vacant receptor
sites at the cell membrane, preferentially in the throat area (where the thyroid gland sits), the face and
sinuses.  The Baroque breeds are suspected by some horsemen to have genetic vulnerability to heavy metal
toxicity; Eastern European warmbloods have a higher incidence of ERU than other breeds.  Thyroid glands
can also be infiltrated by lymphocytes, which translates into reduced thyroid hormone producing tissue and
lowered T3 and T4.  Both Bartonella and Borrelia (lyme) rob their hosts of specific nutrients; these same
deficiencies just happen to be associated with sub-par thyroid function: magnesium, manganese, copper,
iron, zinc, iodine, and vitamins A, C, D, B2, B6, B9 and B12.  The thyroid uses tyrosine and iodine to produce
T3 and T4, a process thought to require manganese.  T3 and T4 production are dependent on dietary
phenylalanine, which requires vitamins B3, B6, C, copper and iron to form tyrosine.  Oxidative stress, a
component of chronic inflammation, contributes to low T3 particularly in the absence of anti-oxidant vitamin E.

Humans and horses with bartonellosis are always 'cold' due to microcirculation deficits.  The presence of a
Bartonella infection within the context of all those characteristics of slower metabolism (low BMR courtesy of
input from the thyroid hormones) facilitates multiple variations in immune mediated manifestations of
disease.  The 'cold' blooded breeds and by extension the 'warm' blooded breeds can be expected to handle a
stealth infection differently from the 'hot' blooded breeds.  Bartonella generates impaired blood supply;
restriction of hemodynamic flow (stasis) will express itself more readily as sudden onset lameness (digital
suspensory syndrome) in a front leg of a sensitive thoroughbred or Arab prone to spikes in blood pressure
under stress, as chronic lameness (laminitis) in small feet supporting a heavy body, and more often as
delayed onset lymphangitis in a hind leg of a heavy breed horse (or as swollen gums where capillary
pressure is lowest farthest from the heart).  Delayed forward phase of stride, a hallmark of Bartonellosis, will
be obvious sooner and appear more frequently in low BMR individuals with slower longer NMJ timing; horses
with genetic faster shorter NMJ timing can outpace their infection induced delays in forward striding until a
critical mass of damage to specific groups of neurons in the brain is reached.  For the lungs, downstream
delays (defined as loss of compliance in physiology) manifest as prolonged recovery times, asthma, COPD,
etc.; the alveoli suffer delayed expansion and contraction forcing the body to increase respiratory rate and
abdominal effort.  Ultimately critical mass for any system in the body is a reflection of site-specific quantal
damage back at mission control: the mid-brain and hypothalamus.  In reality horses with Shivers are
inevitably 'lame' in all four legs (usually RH>LH>LF>RF) in direct proportion to degree of infection.  Historically
Shivers was considered a disease of middle aged draft horses mainly, warmbloods occasionally (larger
individuals), ponies never, geldings mainly and mares rarely.  Those days / centuries / millenia are over.  As
of the current century, most soy (the highly estrogenic protein source in commercial horse feeds) is GMO.  
Most hay and grain crops are now sprayed with glyphosate which promotes LGS and subsequent vitamin
deficiencies.  Internal biochemical environments are repeatedly assaulted by humans administering modern
chemical dewormers.  For ever increasing numbers of horses with chronic infection(s), adrenal glands
clogged by neurotoxins get trapped in a repetitive loop generating high serum cortisol, increased likelihood of
multiple co-infections and dysregulation of sex hormone synthesis.  Sex hormones contribute to BMR (intact
males have a higher BMR than intact females) and their dysregulation manifests differently in different
sexes.  Adrenal health has a much closer relationship to testosterone than to estrogen and progesterone.  
Sacroiliac (adrenal) area pain (CRPS) is another hallmark of bartonellosis in horses; by the time a male
horse develops Shivers, it will stand 'parked out' most of the time giving the appearance of straining to
urinate.  Factors that further lower BMR and adversely effect the thyroid and adrenals are castration, age,
starvation diets and iodine deprivation.  Individuals that have been castrated, are middle aged or older,
harbor chronic infection(s) (with concomittant low T3, high cortisol, etc.), and have an inherited low baseline
BMR (naturally cold blooded) are at higher risk for loss of lean muscle mass (topline) and Shivers.  Due to
overwhelming adrenal exhaustion, net lowered testosterone and net lowered BMR they become far too cold.  
Extremities suffer extreme lack of perfusion; feet should be warm not cold, tails should not clamp at the
slightest touch and teeth should not be hypersensitive.  Mares are at less risk due to their relative lack of
testosterone; despite a healthy amount of neuroprotective progesterone they can become 'hot' and wring their
tails due to disproportionate estrogen.  Similarly, acquired infertility in stallions (and mares) with upstream
hypothalamic, thyroid and adrenal gland distress is well within the repertoire of Bartonella bacteria.  The
author has seen cribbing (for no apparent reason) in a six month old Welsh pony colt as well as Shivers in an
older nutritionally stressed (starved) mixed breed small pony mare (with dropped head syndrome, recurring
laminitis, hallucinogenic behavior, chronic fatigue, uveitis and numerous other symptoms consistent with
bartonellosis) and Shivers in a middle aged heavy Irish Sport Horse mare previously dosed with synthetic
progesterone because she was 'difficult' to break as a two year old.  Stress is cumulative and internal
environments, more stressful than ever before (such as tissues deprived of T3 and/or oxygen due to
bartonellosis and/or lyme), are starting to impinge on neurochemical, thyroid and adrenal balance across
breed divisions in ways previously non-problematic.

Regardless of breed most scientists agree that all autoimmune problems descend from two factors: genetic
predisposition and environmental stress (poor nutrition, repeated ingestion of hay and grain sprayed with
chemicals, exposure to external electromagnetic radiation, chronic infection such as Bartonellosis, etc.).  
Numerically the draft horse breeds and some European warmblood breeds have gone through a period over
the last hundred years of net gene pool shrinkage.  Draft horses have been replaced by tractors and
carriages by automobiles.  Simultaneously modern farming practices have precipitated near total depletion of
minerals from the soil and the crops grown in those soils.  Minerals available to horses a century ago are
absent in today's hay crops and grains.  This amounts to metabolic stress for grazing animals, who are
forced to use energy draining convoluted body chemistry in lieu of the DNA designated pathways nature
intended.  When was the last time any of us saw Lanthanum on a feed bag label?  Lanthanum is the rare
earth mineral associated in the genetic code with phenylalanine, the amino acid precursor of tyrosine
(thyroid) and neurotransmitters dopamine (brain) and epinephron (adrenals).  (Tyrosine and iodine are the
building blocks of T3 and T4; tyrosine is also used by the adrenals to produce epinephron.)  As previously
discussed, low dopamine has been associated with neurologic impairment and explosive behavior;
hypothalamic neurons have been associated with aggression.  Which brings us back full circle to the fact that
many chronic immune mediated and autoimmune states mimic each other.  When the clinical symptom lists
for magnesium deficiency, low T3, low dopamine, low serotonin, fibromyalgia syndrome, chronic fatigue
syndrome, bartonellosis and lyme disease are superimposed on each other, they overlap uniformly.  Adding
accelerant to the fire, there is growing anecdotal evidence that Bartonella can be passed through the mare's
placenta to the offspring.  If a mare is infected she is at risk for placentitis, retained placenta, endometritis,
etc. and her foal's brain, thyroid and adrenal glands are vulnerable.  If that foal matures to breeding age and
carries a subclinical stealth infection, recognized as such or not, the stage is set for an abundance of
immune mediated problems in adulthood that can potentially carry over to succeeding generations.  
Increasing numbers of regressive management nightmares (Shivers, ERU, asthma, COPD, etc.) amount to
sentinels for stealth infection spread.

Ultimately Bartonella reigns supreme over other infections; as a stealth pathogen it transmutes other
pathogens into static layers of blankets under which it can elude detection.  Predictably it will stalk and
suppress multiple co-infectious agents, much like a ransom virus holds hostage a computer.  An example
from the 1980's is protozoal myelitis (EPM); it was only a few years after the advent of ivermectin that EPM first
appeared in horses despite the fact that those same infectious protozoa have lived in nature for thousands of
years.  Over succeeding decades the acute form of EPM has diminished into a far less debilitating condition.  
Very few domestic large animals (horses, cattle, etc.) in North America have never been administered
ivermectin.  It lingers for years in the soil via horse manure.  A neurotoxic inhibitory neurotransmitter (GABA)
agonist, ivermectin delays muscle contraction; Bartonella, which already owns first, second and third bases
(the brain, thyroid and adrenals) simply elevates its game.  Wearing invisible t-shirts that say “Co-infections
Welcome Here”, Bartonella horses are magnets for 'outbreaks' of EPM, monocytic ehrlichiosis (potomac
horse fever), Corynebacterium pseudotuberculosis (pigeon fever), Borrelia (lyme disease), babesiosis and
(in foals recently weaned) Rhodococcus equi.  Even a clostridial infection like C. tetani is not necessarily a
death sentence for a horse with a chronic Bartonella infection; horses can recover from tetanus, EPM, etc. if
they are treated for underlying bartonellosis.  Assuming chronic infection has been addressed with infection
fighting herbal formulas starting orally at the level of the gut, restorative nutrition will influence the immune
system to go back to work more competently.  Immune support mandates consideration for the thyroid and
adrenal glands, specifically availability of phenylalanine, tyrosine and iodine.  Diet alone supplies
phenylalanine (an essential amino acid) found in mares' milk (high levels), wheat germ and oats (low
levels).  It can directly affect brain chemistry by stimulating endorphin production.  Chronic infection inevitably
leads to chronic inflammation which lowers endorphin levels.  (Horses that crib are addressing pain by
raising their endorphin levels.)  In addition to lowering endorphins, chronic inflammation in and of itself
immobolizes the thyroid.  Controlling it allows the brain, thyroid and adrenals a window of opportunity to re-
calibrate their various and assorted functions such as thermoregulation, neurotransmitter balancing and
hormone regulation.

Low dose naltrexone (LDN), a compounded drug, is the 'go to' treatment of choice for reducing long term
chronic inflammation and oxidative stress.  It appears to work by balancing Th1 and Th2 dominance, both of
which can be simultaneously overactive or underactive.  By virtue of the fact that it blocks opioid receptors, it
signals the brain to dial up production of endorphins thereby reducing a Bartonella horse's incentive for
cribbing.  LDN has been shown to reduce (and in some cases eliminate) symptoms of FMS (see The
Fibromyalgia Horse), histamine intolerance (severe itching on the head, neck and/or chest), chronic regional
pain syndrome (CRPS) (100% of Bartonella horses have sacroiliac adrenal regional pain), irritable bowel
syndrome (IBS/LGS) and autoimmune thyroiditis.  Best of all, it works at sites where Bartonella henselae
tends to persist as in bone marrow.  LDN enhances maturation of exceedingly potent dendritic cells from
stem cells; upon migrating from bone marrow to blood and lymphoid tissues (peripheral niches for
Bartonella), dendritic cells modulate B and T lymphocytes and reorganize appropriate immune responses.  
Patients with neurodegenerative diseases characterized by low dopamine improve on LDN much like
recipients of stem cell transplants.  LDN should not be given with thyroid replacement therapy concurrently
unless response to TRT alone has been evaluated.  Low cost and ease of administration add to its user
friendliness; like magnesium and iodine, it can be given transdermally, bypassing the gut.  The inside of the
groin and the underside of the tail are ideal places to apply transdermal LDN.  It is important to use a
pharmacy that specializes in compounding LDN (see Resources below).  Unlike  anti-inflammatories and
thyroid replacement therapies, LDN reverses chronic inflammation cascades paving the way for
normalization of thyroid and adrenal gland responsiveness.  When employed for specific immune mediated
conditions (Shivers, ERU, IBS, laminitis, cribbing, etc.), a wide range of seemingly unrelated issues
concurrently begin to resolve, providing broad spectrum relief.  Availability of LDN presents today's horse
owners and veterinarians with unique opportunities to more fully appreciate chronic inflammation's all
encompassing stranglehold on Bartonella horse health.  On their journey back to wellness these horses are
set free to gradually recoup their true peaceful nature.


“We return victorious to the spirit, having descended into hell.  And from hell we bring trophies.  
Understanding is one of our trophies.”      -Don Juan Matus


Resources

www.antennasearch.com  (free search for all towers and antennas within a 4 mile radius of your barn)

www.wholesomeequinenutrition.com (Karen Bates, USA) / 561-601-2310 / wholefoodsforhorses@gmail.com

www.copperfieldequinetherapy.com (Catherine Cooper, Ire) / +353 (0)62 53940 / catherinecooper@eircom.
net

www.GeorgiaEquineDentistry.com (Diane Febles, DVM, CVA) / 770-954-0793 / DianeDVM1@charter.net   

www.redmondequine.com  (Redmond Daily Gold Stress Relief mineral supplement)

www.stanceequine.com  (shredded coconut “Cool Stance” for horses available in Australia, New Zealand,
South Africa, United Kingdom and USA) / www.stanceequineusa.com / 803-647-1200

www.homeopet.com (Equiopathics homeopathic dewormer “Horse Clear”) / 800-555-4461

www.skipspharmacy.com (compounding pharmacy specializing in LDN and veterinary prescriptions) / Boca
Raton, Florida / 800-553-7429 / info@skipspharmacy.com

“Light Relief” infrared pain relief device for CRPS (www.amazon.com key words infrared light therapy)      

“The Immune Laminitis Connection” @ www.forloveofthehorse.com

“A Survey of Adverse Effects Associated with Ivermectin Use in Louisiana Horses” 1984 JAVMA @  www.ncbi.
nlm.nih.gov>pubmed         

Minerals for the Genetic Code by Charles Walters @ www.amazon.com/books

Detoxify or Die by Sherry A. Rogers, MD @ www.amazon.com/books

LDN fact sheets, LDN and autoimmune diseases @ www.ldnresearchtrust.org
access LDN research and video “How LDN Works” @ www.ldnscience.org
If you cannot view the above video please click the link below.
You will be redirected to You Tube to view the same video.
FREQUENTLY ASKED QUESTIONS

Copyright August 1, 2015 (last updated August 1, 2017)
All rights reserved.
No part of this publication may be reproduced, stored in a retrieval system or transmitted, in any form or by any means,
without prior written permission of the author.



1.        WHAT DOES BARTONELLA IN A HORSE LOOK LIKE ?

As a stealth pathogen, Bartonella is adept at staying under the radar of human recognition underneath a multitude of
disguises.  Clinical signs of a chronic Bartonella infection are mysterious in onset, appearance, severity and duration
(periodicity).  A relapsing bacteremia is expressed as multiple recurring deficiencies, a sliding scale of dysfunction much like
a roller coaster; various system imbalances can produce polar opposite symptoms.  Just like autism spectrum disorder,
chronic Bartonellosis will induce a vastly different constellation of symptoms from one horse to the next.  “Stress is
cumulative” and so are the clues that reflect a lurking problem that defies description.  Since the trajectory over time is
toward autoimmunity, those conditions that correlate with serious immune system dysfunction (notated ***) are significant
red flags in and of themselves; the presence of just a few of the many conditions listed here constitute grounds for further
investigation into the possibility of chronic Bartonellosis.



SYMPTOM CHECK LIST
(How many of these clues can you recognize in your horse?)


Lethargy / Chronic Fatigue Syndrome / Poor Exercise Tolerance
      
      chronic inflammation in a wide range of tissues including the brain, bone marrow
delayed forward phase of stride at any or all gaits (slow bringing the leg(s) forward)

                      extensor rigidity / contracted flexor tendons
                      subluxating pasterns and/or fetlocks
                      upright angles (straight) in the fetlocks and pasterns
                      tendency to land toe first
                      dragging toes / toes worn flat
                      hanging one or both knees over a jump
                      hitting jumps with one or both hind shins
                      subluxating patella(s) (locking stifles)
                      curb (ruptured plantar ligament)
                      sesamoid bone fracture(s)
                      tallus fracture(s)
                       forging (clicking front heels with hind toes)
      abrasions on front of pasterns from difficulty standing up        
      riding “as if the hand brake has not been released”
      poor exercise tolerance
      refusal to move forward (with or without rearing)
      reluctance to bear weight on sore feet (hypersensitive soles)
                      
          muscle deconditioning and/or muscle spasms

                      total body soreness / uncomfortable posture
                      digital suspensory syndrome
                      carpal tunnel syndrome
                      back soreness, topline muscle atrophy
                      chronic regional pain syndrome (CRPS) in sacroiliac area ***
                      dropped head syndrome
                      tendency to travel hollow backed and high headed
                      skipping / cross cantering / cross firing at the canter
                      fibromyalgia (EFMS) *** (see “The Fibromyalgia Horse”)
                      grunting / moaning / groaning under saddle
                      diaphragmatic muscle spasms (hiccups aka thumps)
                      esophageal rotation within the diaphragm
                      esophageal muscle spasms (choke, swallowing problems)
                      laryngeal muscle spasms
                      displaced soft palate (with or without holding the breath)
                      chronic intercostal muscle soreness, cramping (ribs)
                      shivers *** (in 1, 2, 3 or 4 legs)
                      rigid muscles between hips and stifles (cording)
                      fibrotic myopathy *** (in one or both hind legs)
                      “thickened suspensories” / annular ligament desmitis (ALD)
                      degenerative suspensory ligament desmitis (DSLD)
                      calcium deposits in tendons / tendon sheaths
                      rupture of the extensor carpi radialis (in one or both forearms)
                      audible ‘snap, crackle, pop’ from stifles and/or hocks ***
                      cardiac muscle fatigue (weak heart valves / systolic murmur)
                      cardiac conduction disturbances / dropped heart beats
                      flaring nostrils at rest (chronic)
                      spontaneous periodic heavy breathing episodes
                      chronic obstructive pulmonary disease (COPD / heaves) ***
                      dribbling urine / odd urination habits
                      retained placenta (uterine atony)
                      leaky gut syndrome
                              constipation /scant dry manure OR diarrhea / colitis
                              herring gutted OR bloated abdomen
                              right dorsal colon ulcers
                              inflammatory bowel disease (IBD) ***
                              abundance of tape worms resistant to deworming
                              overgrowth of Candida in the large intestine
                              malabsorption of nutrients
                              gas colic (chronic)
                                      epiploic foramen entrapment (seen at colic surgery)
                                      gastrosplenic ligament entrapment (ditto)
                      stringhalt *** (in one or both hind legs)
                      neuritis of the cauda equina / polyneuritis ***
                      peripheral myoclonus
                      wobbler syndrome / intervertebral disc disease
                      ‘neuro crab walking’ / ‘sidewinders syndrome’ ***

      shifting leg lameness

                      lameness that shifts from front to back and/or side to side
                      “bridle lameness” (commonly lame on one diagonal)
                      frequent tripping on even and/or uneven ground
                      “stiff leg syndrome” (micro muscle spasms)


Microcirculation Deficits

    sensitivity to cold weather, particularly cold and rain (regardless of blanketing)
    absence of dapples (branches of the capillary tree)
    pale mucous membranes (in mouth, pale tongue)
    tendency to bleed

                            increased central arterial and venous pressure
                            thrombocytopenia (low platelet counts)
                      thrombocytopenic purpura ***
                            prolonged clotting time
                      exercise induced pulmonary hemorrhage (EIPH) ***
                      spontaneous (non-exercise induced) nosebleeds
                      vasoproliferative tumors (malignant melanoma)
                      progressive ethmoid hematoma
                      autoimmune hemolytic anemia (AIHA) ***
                      
    complications associated with poor tissue oxygenation

                      prolonged healing time (> 7 to 10 days)
                      surgical repair failures
                              wound dehiscence
                              fracture site non-unions
                              colic surgery anastomosis break-down        
                      recurring ‘scratches’
                      scirrhous cord following castration
                      yeast-like secretions in the sheath (geldings and stallions)
                      low grade chronic endometritis ( mares)
                      placentitis in pregnant mares
                      overgrowth of organisms that thrive in low oxygen locales
                              maggots in poorly perfused wounds (Rx: desitin)
                              chronic thrush in and around the frogs
                              tape worms
                      presence of common co-infections *** (all of these)
                              lyme disease (Borrelia)
                              babesiosis (Babesia) (Piroplasmosis)
                                protozoa (EPM in the cerebrospinal space)
                              toxoplasmosis (chronic)
                              leptospirosis (chronic)
                              tetanus (Clostridium tetani)
                              botulism (Clostridium botulinum)
                              “bastard strangles” (Strep equi) ***
                              salmonellosis (Salmonella sp.)
                              pigeon fever (Corynebacterium pseudotuberculosis)
                              fungal conditions resistant to treatment (“rain rot”)
                              chronic bacterial foot abscesses and/or subsolar abscesses
                              brucellosis
                                      poll evil ***
                                      fistulous withers ***
                              late summer foal pneumonia (Rhodococcus equi)
                              Lawsonia intracellularis

    quittor (necrosis of the collateral cartilage)
    EOTRH (hypercementosis) +/- sensitive teeth +/- swollen gums ***
    frostbite (commonly the tips of the ears)
    chronic laminitis ***
    chronic exertional rhabdomyolysis (tying-up) (muscle damage and bleeding)
    periodic paresis (tying-up) at rest
    cording of lymphatic vessels
    generalized lymphadenopathy ***
    axillary / inguinal lymphangitis ***
    pedal osteitis
    lymphangitis (commonly in a hind leg previously injured)
    cellulitis (recurring)
    swollen liver (hepatomegaly)
    swollen spleen (splenomegaly)
    swollen joints (knees, hocks, stifles)
    pericarditis (swollen pericardium)
    peroneal nerve paralysis (consequence of a hind leg stuck under a fence)
    radial nerve paralysis (historically linked to ill-fitting neck collars)


Head and Neck Issues

    swollen eyelids
    surface eye infections with tearing
    random cranial nerve dysfunction

                              optic nerve
                                      micro-ophthalmia (one or both eyes)
                                      blindness (one or both eyes, normal outwardly)
                                      ERU (equine recurrent uveitis) ***
                                      autoimmune keratitis ***
                                      depth perception deficits (altered spatial behavior)
                                      preference for shade vs. bright light (sore eyes) or
                                      refusal to move from bright light to dark shade
                                      head shaking (photic) (Rx: guardian mask)
                              olfactory nerve
                                      flehmen response (repetitive)
                              facial nerve
mouthiness
                                      cribbing *** (various manifestations)
                                      nipping, biting, licking
                                      chewing wood
                                      facial nerve paralysis (Bell’s Palsy)
                                      teeth grinding / jaw clenching
                              vestibulocochlear nerve
hypersensitivity to sound (for example clippers)
balance problems (in a moving horse trailer)
                              trigeminal nerve
                                      pruritis (itchy head during and after exercise)
                                      exercise induced trigeminal neuralgia

head shaking (non-photic)
                              hypoglossal nerve       
                                      tongue laxity
                                      tongue pruritis (histamine intolerance)
                                      odd compulsive habits involving the tongue
                                      hypoglossal nerve palsy

    neurogenic atrophy of various head and neck muscles (masseter, supraspinatus, etc.)
    temporomandibular osteoarthropathy (TMO)
    entrapment of the epiglottis and/or soft palate problems
    recurrent laryngeal nerve paralysis, partial paralysis, roaring
    recurrent airway disease (RAD)
    impaired drainage from salivary glands (mainly the parotids)
    choke (that does not resolve without veterinary intervention) ***
    dry mouth or excessive salivation
    megesophagus (food lodges in the esophagus) ***
    goiter (enlarged thyroid gland)
    sweet itch (topline pruritis along base of mane and/or base of tail)
    alopecia areata (aka vitilago) (hair loss around eyes and/or muzzle) ***
    equine sarcoid ***
    squamous cell carcinoma
    adenocarcinoma
    head pressing (headaches)



Endocrine / Neurochemical Imbalances *** (all of these)

    anhydrosis  (non-sweater) OR excessive sweating
    sudden total body hair loss / total loss of hair on the head
    hyper-reactivity to repetitive vaccination (localized soft tissue inflammation)
    delayed systemic allergic reaction to vaccination (colic / laminitis within 30 days)
    mast cell activation syndrome ***
    severe allergic reactions to intravenous drugs
    endocrinologic laminitis
    food allergies
    sensitive skin
                              callouses on one or both elbows
                              chronic “shoe boils” / capped elbow(s)
                              hypersensitivity to touch (ears, face, hind legs, blankets)
                              hypersensitivity to rain / bathing
                              hypersensitivity to strong sunlight (sun burn)
                              hypersensitivity to grooming tools
                              hypersensitivity to certain bedding
                              reactivity on girthing / hypersensitivity to tack
                              reactivity to shampoos, fly sprays, detergents, leather dye
                              hypersensitivity to insects and insect bites
                                      sweet itch (mane and/or tail)
                                      intense pruritis along ventral midline, sheath / udder

    hair that stands on end in a linear pattern (along meridians)
    static electricity under blankets
    birdcatcher spots (first documented in the Irish TB stallion Birdcatcher 1833-1860)
    “skunk tail” (especially in combination with alopecia areata and/or birdcatcher spots)
    neurotransmitter imbalances (neuroses)
                              explosive outbursts (low dopamine) (ex: bolting)
                              depression (low serotonin)
                              anger, aggression, temper tantrums
                              moodiness, grumpiness, argumentative attitude
                              changes in temperament (mild mannered to a bully)
                              panic attacks (fear based) (for little or no reason)
                              running backwards (during a panic attack)
                              violently pulling back while tied
                              tendency to kick walls, humans, other horses (violently)
                              tendency to dorsiflex violently and randomly (buck)
                              hallucinations / bizarre fearful behavior
                              frequent yawning (yawning resets neurotransmitters)
                              narcolepsy (falling asleep randomly and/or collapsing)
                              random seizures
                              proprioceptive deficits (anywhere on the body)
                              attention deficit/hyperactivity disorder

    insulin resistance
    cushing’s syndrome (early onset high serum cortisol)
    peripheral Cushing’s
    equine metabolic syndrome (EMS)
    altered estrus cycles (short or long, flagrant or silent)
    cystic ovaries
    chronic intermittent lactation (over months, years)
    prolapsed uterus and/or retained placenta (after foaling)
    testicles that are slow to fully descend / cryptorchidism (linked to ill behavior)
    low testosterone / shy breeders
    mineral depletion  (Bartonella feeds on magnesium)

                              consistently inconsistent behavior from one day to the next
                                      and/or from one season to the next
                                    dangerously high levels of toxic metals on hair analysis
                                      lead
                                      aluminum
                                      copper
                                      arsenic
                                      mercury
                                      selenium
                              patchy sweating (magnesium +/- potassium depletion)        
                              inability to relax (muscle twitching / trembling / prancing)
                              self mutilation (biting at chest)
                              repetitive behavior (weaving, stall walking, pacing)
                              neurotic separation anxiety
                              obsessive compulsive behavior patterns (OCD)
                              tendency to escape from normal horse enclosures
                              inability to tolerate changes in routines
                              shortened stride length going downhill
                              oxidative stress / improvement with large doses vitamin E
                              marked improvement with 10 grams Mg malate /day in diet        


                          
2.        IS THERE A TEST ?


Bartonella produces a relapsing bacteremia; some days it is floating freely in the circulation and some days not.  For this
reason, our chances of obtaining a positive test result are enhanced by collecting blood samples on at least 3 alternate days.  
The veterinarian sends all 3 samples with a completed submission form to Galaxy Diagnostics (www.galaxydx.com).  Turn
around time for test results is 3 weeks.  Galaxy uses a technology (BAPGM) that is considered the gold standard in Bartonella
testing.  For more information visit their website.  Additional information regarding ePCR testing can be found in the research
article “Enrichment Blood Culture Isolation of Bartonella henselae from Horses with Chronic Circulatory, Musculoskeletal
and/or Neurologic Deficits” (Journal of Advances in Biotechnology and Microbiology, volume 4 issue 5).  

                                                                                            
PDF DOWNLOAD HERE


3.        WHAT IS THE CURRENT TREATMENT OF CHOICE ?


For best results, the Total Infection Clearing Kit (TICK) (“Copperfield Gold”), a combination of 3 staged herbal formulas, is
superior in efficacy, user friendliness and safety for the horse.  It is available from www.copperfieldequinetherapy.com.  Most
horses go through a mild healing crisis which amounts to a few days of tiredness followed by steady gradual return to good
health.  Additional nutritional support is necessary as long as the horse’s body remains depleted with respect to magnesium
in particular.  As of August 1, 2017 this protocol has addressed the following successfully:

respiratory tract infections / chronic mucus
recurrent airway disease (RAD)
spontaneous periodic heavy breathing
chronic obstructive pulmonary disease (COPD / heaves)
exercise induced pulmonary hemorrhage (EIPH / bursting)
microcirculation deficit disorder
lymphangitis / recurring cellulitis
muscle deconditioning / muscle spasms
hypersensitivity to touch
topline muscle atrophy
sacroiliac pain
poor exercise tolerance
total body soreness
exertional rhabdomyolysis (tying-up)
arthritis / joint inflammation
audible “snap, crackle, pop” from hocks and/or stifles
kissing spines
stringhalt, shivers, wobbler syndrome
digital suspensory syndrome
chronic bacterial foot abscesses
laminitis
hypersensitive soles
chronic thrush
leaky gut syndrome
gastric and/or colonic ulcers
head shaking / seasonal allergies
depression, hallucinations
moodiness, grumpiness, argumentative attitude
anger, aggression, temper tantrums
cribbing / obsessive compulsive behavior(s)


4.        CAN A BARTONELLA INFECTION BE INHERITED ?


Yes.  Evidence for transmission of infection from mother to offspring has been demonstrated in small rodents.  There is
growing anecdotal evidence that larger mammals (humans, horses) can also pass the infection along from one generation to
the next.  Much work needs to be done to elucidate this aspect of Bartonella epidemiology.  


5.        HOW DOES A HORSE ACQUIRE BARTONELLOSIS ?


The usual mode of transmission to horses appears to be biting insect vectors: biting flies, mosquitos, ticks, dog fleas and cat
fleas.  Immature immune systems (orphan foals and foals weaned too early) are particularly vulnerable as seasons change
(end of summer, early fall) when many insects go into a feeding frenzy prior to onset of winter and below freezing (insect
killing) temperatures.  Many horsemen find that white, grey and palomino horses are more attractive to biting insects than
dark colored horses.




“You are never given a wish without also being given the power to make it true.  
You may have to work for it, however.”                   -Richard Bach





            
  



                    
Contributions from Equine Veterinarians


“......I diagnose a lot of EOTRH (Hypercementosis) in horses.  Mostly older warmblood geldings, males
more frequently than females.  Western medicine has nothing to offer except extraction of all incisors.  I use
and recommend a mushroom product called Equident and have had amazing success in stopping
progression of the disease.  I think there is a correlation between the two diseases <EOTRH and
Bartonellosis>......”                          -Diane Febles, DVM, CVA (Veterinary Equine Dentistry and Acupuncture)

   “Why is there soy in horse feed?  Soy is a cheap form of protein.  It is highly estrogenic so it should never
be fed to horses with any type of metabolic disorder like Hypothyroidism, Insulin Resistance or Cushing's
Syndrome.  99.9% of soy is genetically modified to be Round-Up Ready.  Glyphosate, one of the active
ingredients, is the leading cause of leaky gut syndrome in horses.  Leaky gut syndrome can cause
allergies, diarrhea, mal-absorption syndrome, colic and irritable bowel syndrome.”    -Mark DePaolo, DVM
(www.depaoloequineconcepts.com)    

 “God never meant for horses to be larger than 16 hands.”   -Bill Moyer, DVM (professor emeritus, Texas
A&M University)
Contributions from Bartonella Horse Owners
Case Report from Hiawassee, Georgia, USA   (thank you Musa Wiles)

My 13 year old gelding Crimson was diagnosed by two veterinarians with COPD/Asthma. His symptoms
were constant coughing, flared nostrils, abdominal lift, weight loss and mucus discharge from his nose.  
Although both agreed there was no cure, just manageability, the standard care offered was steroid
injections, bronchodilators and the like. The prognosis was manage as well as possible, but one day he’d
have to be put down due to his struggle to breathe. Unwilling to accept this prognosis, I started researching
and came to change his diet to a completely non-gmo, whole food diet, as well as, came upon Dr. Brenda
Bishop through an article I read, and called her. She pointed me to the Bartonella Kit.
I am delighted to report that my horse is healed! All the symptoms are gone, he is better than ever. The two
vets just scratch their heads, but there is no denying that my horse is completely healthy.  Many thanks go to
professionals like Dr. Bishop for thinking outside the box and looking for all natural remedies to chronic
diseases. My horse’s life was saved as a result.
Case Report from Waddell, Arizona, USA  (thank you Carol Stinner)


“Lily is a 9 year old grey warmblood mare who after being started at age 4 had issues: no forward, grumpy,
bucked and would stop then not take one more step forward or rear.  In 2014 Lily spent a few months at a
large working cattle ranch in Arizona where she did well but worked very hard both physically and mentally.  
After returning home all heck broke out and she was then visibly ill for 2 years.  She was treated with
conventional medicine for stomache and hind-gut ulcers, systemic bacterial infections, even endometritis,
which was diagnosed after a biopsy and ultrasound reproductive work-up.  She became depressed, lethargic,
hypersensitive to sound, and had severe fibromyalgia.  Lily began the Bartonella herbal treatment from
Effective Pet Wellness in January 2016.  She layed down and rested a lot but progress towards health was
slowly happening!  I chose to treat her with advanced herbal therapy after the Bartonella cleared, to help heal
the damage to her body after 5-6 years of illness.  We recently started riding again after 2 years off and it is a
miracle!  I have a lovely, FORWARD, soft, responsive, happy mare.  Lily was supposed to be my amateur
dressage horse but I am now humbled as a horsewoman to see what Lily has endured.  Therefore we will
enjoy each ride and do what she loves…trail riding in the beautiful Arizona desert!”
Biting Insect Repellent Spray Formulas (contributed by Paula Denardo, N.C., USA)        
Mix in a 16 ounce spray bottle:

½ teaspoon vegetable glycerine
14 ounces witch hazel
40 drops of essential oils (choose one of the following options)
                        Fly Option:                20 drops lavender
                                                10 drops mint
                                                10 drops rosemary
                        Tick Option:
                                                20 drops eucalyptus
                                                10 drops lavender
                                                10 drops peppermint
                        Mosquito Option:
                                                10 drops eucalyptus
                                                20 drops citronella
                                                10 drops lemon
Case Report from Ft. Myers, Florida, USA (generously contributed by Julie Griffin)

“Luna” is a grey 12 year old Oldenburg/Thoroughbred mare.  “Luna was destructive in her stall, unpredictable, antsy,
anxious.  No topline, hard to keep weight on.  Came into heat every two weeks.  Her hind end was weak, and you could
not groom her without objection.  Now having completed the holistic treatment, she keeps a clean stall, enjoys grooming,
is calm and has a topline.  She is easier to train and is engaging her hind end.”






















“This is Luna, after one class at 2nd level.  She is starting treatment today.” (April 2015)
(Comments: This is a typical posture for a Bartonella horse.  She is stretching out her brachial (shoulder) plexus,
bundles of sore lymphatics, and cocking her hind leg to relieve the inguinal plexus area.)

























One year later Luna is training at 3rd level.  March 2016
“The top photo is Luna (February 2015) before the Bartonella treatment.  The bottom is March 2016.  As you can see
Luna’s back is hollow, head is up, tense in the back, tail out and not swinging back and forth as a tail should be in a
relaxed back.  She is not using her back end effectively and you can see her hind end trailing a bit.  Spooking at anything
to get out of work, short attention span, she is bleached out in her coat.  The rider would have to push her to move
forward as you see in her position and fight to keep her on the bit.  After treatment she is more relaxed in the back and
her tail is swinging back and forth.  She is using her hind end better and is getting some more air time because of it.  
Luna has a better work ethic and is no longer spooking and is accepting the bit.  She has more dapples and has put on
100 pounds of top line muscles.  The rider can sit the trot better, she no longer needs to push for every step, and the
horse now has self carriage.”  
Case Report from Roanoke, Virginia, USA      
(thank you Susie Whiteside)

“My horse Boomer, now a 3+ year old Shire/Appaloosa cross gelding, was sick for the entire first year I owned him, as
we struggled to find the exact cause.  After treating with traditional antibiotics for Lyme, we still had many symptoms that
were progressively getting worse.  Exploring Shivers, EPM, PSSM and even Wobblers Syndrome, I was ultimately facing
euthanasia and actually had it scheduled!  With Dr. Bishop’s advice and recommendation, I put my very sick horse on
the Bartonella and Mycoplasma herbal protocol from Copperfield Equine in Ireland, administered by Catherine Cooper.  
We had amazing results in just a few months!  My horse could hardly stand and was miserable.  Now he is comfortable,
bright and energetic, shiny and healthy, and we are actually riding together again!  I am beyond grateful for both Dr.
Bishop’s and Catherine Cooper’s guidance and help, long-distance no less, as they came together to save my horse!”
Naturopathic Tick Prevention Formula
(thank you Tara Badorek, Connecticut, USA)

This Tick Prevention Tincture formula is a basic tincture 1:4 50% of the following:

Andrographis                        Cat’s Claw                        Neem Leaf
Astragalus Root                Japanese Knotweed                Flower Essence of Garlic

Mix 1oz of each of the above except the Flower Essence of Garlic (use 16 drops) in a 50/50 grain alcohol, distilled water
menstrum.  Let it sit 6 to 8 weeks, with a daily shake.  Use a French press and a cheese cloth to extract the liquid.

Administer ½ teaspoon to ¾ teaspoon per day per horse orally during tick season.        
Case Report from Seagrove, N.C., USA       (thanks to Karen and Joe Campbell)

Here is an old picture of Joe roping on Zane and a recent picture.  We are very pleased; without Catherine’s herbs
Zane would still be a WRECK.  He looks healthier than ever and feels so much better.  Joe finally put a saddle on him
yesterday and rode him lightly.  He didn’t show any of his usual signs of pain when saddled as before.  And he didn’t
try to jump out from under Joe when he got on and off which he did terribly before.  He had his liveliness back and had
pep in his step walking forward where before he didn’t even want to walk!  He has about a week of Stage 3 left to go.  
Zane looks so much healthier and happier now.  Thank you for putting us in touch with Catherine Cooper.  We are
truly impressed with these herbs.